Absorbable
Polymer:
a polymer
which
when exposed
to a biological
environment
is absorbed
by the
biological
environment.
The polymer
may be
merely
absorbed
(dissolved)
without
degradation
by the
host;
or, it
may be
degraded
as part
of the
absorption
process.
Biodegradable
Polymer:
A polymer
which
when exposed
to a biological
environment
degrades
into smaller
chemical
units.
Degradation
may take
place
by a variety
of mechanisms;
however,
hydrolysis
is the
most common.
PRODUCTS
We
offer
the
following
standard
products
:
|
Polymer
|
Common
Name
|
Inherent
Viscosity*
|
|
50/50
poly(DL-lactide-co-glycolide)
|
50/50
DLPLG
|
0.15
-
0.25
|
|
50/50
poly(DL-lactide-co-glycolide)
|
50/50
DLPLG
|
0.26
-
0.54
|
|
50/50
poly(DL-lactide-co-glycolide)
|
50/50
DLPLG
|
0.55
-
0.75
|
|
50/50
poly(DL-lactide-co-glycolide)
|
50/50
DLPLG
|
0.76
-
0.94
|
|
50/50
poly(DL-lactide-co-glycolide)
|
50/50
DLPLG
|
0.95
-
1.20
|
|
65/35
poly(DL-lactide-co-glycolide)
|
65/35
DLPLG
|
0.55
-
0.75
|
|
75/25
poly(DL-lactide-co-glycolide)
|
75/25
DLPLG
|
0.55
-
0.75
|
|
85/15
poly(DL-lactide-co-glycolide)
|
85/15
DLPLG
|
0.55
-
0.75
|
|
poly(DL-lactide-co-glycolide)-COOH
|
50/50
DLPLG-COOH
|
0.15
-
0.25
|
|
poly(DL-lactide-co-glycolide)-COOH
|
50/50
DLPLG-COOH
|
0.55
-
0.75
|
|
poly(DL-lactide)
|
DLPLA
|
0.26
-
0.54
|
|
poly(DL-lactide)
|
DLPLA
|
0.55
-
0.75
|
|
poly(DL-lactide-COOH)
|
DLPLA-COOH
|
0.15
-
0.25
|
|
poly(DL-lactide-COOH)
|
DLPLA-COOH
|
0.26
-
0.54
|
|
poly(L-lactide)
|
LPLA
|
0.90
-
1.2
|
|
poly(
e-caprolactone)
|
PCL
|
1.0
-
1.3
|
|
25/75
poly(DL-lactide-co-caprolactone)
|
25/75
DLPLCL
|
0.70
-
0.90
|
|
75/25
poly(DL-lactide-co-caprolactone)
|
80/20
DLPLCL
|
0.70
-
0.90
|
*Inherent
viscosity
of
50/50
DLPLG,
65/35
DLPLG
and
PGA
measured
in
hexafluoroisopropanol.
The
inherent
viscosity
of
other
polymers
measured
in
chloroform.
Sample
Kits
are
also
available. |
Product
quality
:
|
The
commitment
to
quality
includes
a
thorough
analysis
of
each
lot
of
polymer.
Polymer
lots
are
tested
before
shipment,
and
each
lot
is
supplied
with
a
Certificate
of
Analysis
(COA).
Our
basic
analyses
include
identification
by
IR
or
1H-NMR,
inherent
viscosity
(IV),
monomer
ratio
by
1H-NMR
(copolymers
only),
residual
Sn+2
(from
catalyst),
bioburden,
and
pyrogens
(LAL).
The
bioburden
tests
include
total
aerobes,
anaerobes,
and
spores.
Other
analyses
can
be
provided
if
desired,
including
other
metals
and
molecular
weight
by
GPC.
|
Custom
synthesis
:
For
many
customers,
API
prepare
custom
polymers
with
specific
characteristics,
such
as
molecular
weight
and
copolymer
ratio.
We
also
tailor
end
groups
of
polymers,
most
commonly
either
acid
or
ester
group,
because
a
subtle
change
in
molecular
architecture
can
have
a
profound
effect
on
water
uptake,
degradation
rate
and
drug
delivery.
They
also
synthesize
copolymers
with
trimethylene
carbonate
and
polyethylene
glycol.
|
|
|
|
